Tottenham's Alan Hutton joins fellow groin injury victims Benoit Assou-Ekotto, Alan Hutton, Aaron Lennon and Jonathan Woodgate on the sidelines.
Ledley King is also out so Sebastien Bassong will play at centre-back.
Hull's Jimmy Bullard is not yet ready for a first-team return but Dean Marney and Paul McShane are back in the squad.
Jozy Altidore has been given compassionate leave to track down relatives caught up in the earthquake that has struck Haiti.
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Tottenham
Suspended: None Doubtful: Pavlyuchenko (groin)
Injured: Cudicini (broken wrists), Assou-Ekotto, Hutton, Lennon & Woodgate (all groin), King (knee)
Hull City
Suspended: None Doubtful: None
Injured/unavailable: Altidore (compassionate leave), Ashbee & Bullard (both knee), Cousin & Olofinjana (Africa Cup of Nations)
After only one game so far in January, Tottenham face a testing five matches in 14 days that will go a long way to shape what has been an highly-impressive campaign so far.
Spurs' free-scoring season was kick-started with a clinical 5-1 demolition of Hull at the KC stadium in August.
But whilst they have despatched most teams at the bottom of the table with consummate ease, home defeats to Stoke and Wolves have given teams a sliver of hope when they travel to White Hart Lane.
And the Tigers of course will not have forgotten their stunning 1-0 win at Tottenham early last season, but much has changed for both clubs since then.
Phil Brown's side were third in the table and had already won at St James' Park and the Emirates, but since that match in October 2008 they have won just twice away from home, while Spurs who were bottom of the league, have propelled themselves up the table and are now firmly in the hunt for a Champions League spot.
Manager Harry Redknapp should be able to bask in his achievements and celebrate what will be his 500th game in charge as a Premier League manager, but charges of tax evasion have left a cloud lingering over the former West Ham, Portsmouth and Southampton boss.