Wigan's Titus Bramble is unlikely to shake off the hamstring injury he picked up against Bolton in midweek.
Aside from that Roberto Martinez only has concerns over Steve Gohouri and Richard Kingson.
Tottenham remain without winger Aaron Lennon, but manager Harry Redknapp announced this week that his groin injury does not require surgery.
Ledley King may be saved for the FA Cup replay with Bolton on Wednesday and Jermaine Jenas faces a late test.
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Wigan (from): Kirkland, Melchiot, Caldwell, Boyce, Figueroa, Scharner, N'Zogbia, Diame, Thomas, McCarthy, Rodallega, Moreno, Moses, Scotland, Sinclair, Stoijkovic, Gomez, Koumas, Watson.
Injured: Bramble and Gohouri (both hamstring), Kingson (muscle tear)
Tottenham (from):Gomes, Alnwick, Corluka, K Walker, Bale, Bassong, Dawson, King, Kaboul, Palacios, Jenas, Huddlestone, Modric, Kranjcar, Bentley, Rose, Pavlyuchenko, Gudjohnsen, Defoe, Crouch.
Doubtful: Jenas (groin)
Injured: Assou-Ekotto (hip), Cudicini (broken wrists), Lennon & Woodgate (both groin)
You can get odds of 500-1 on either side managing a repeat of the 9-1 scoreline Tottenham racked up in the reverse fixture in November.
But Tottenham's magic touch in front of goal has deserted them of late and Wigan have only scored more than one goal in a league match once since mid-December.
Tottenham's travails away from home, and their distinct lack of goals, is a concern for manager Harry Redknapp. Shorn of the injured Aaron Lennon, sides have worked Tottenham's tactics out and the lack of a decent supply line to Jermain Defoe and close marking of Peter Crouch has seen Spurs score just once away from home in their last four league matches.
Earlier this week Redknapp bemoaned his side's lack of a Frank Lampard figure who can weigh in with 20 goals a season, not surprising given that his central midfield duo of Tom Huddlestone and Wilson Palacios have scored just two league goals between them this term.
Wigan boss Roberto Martinez says his side must "cash in" on their home fixtures if they are to steer clear of the relegation zone.
Easier said than done when the surface at the DW Stadium has been churned up by a combination of bad weather, football and the start of the rugby league season. It is not likely to be conducive to the passing game both sides like to play, so a 9-1 scoreline looks like a bet definitely worth avoiding.
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