Sunderland goalkeeper Craig Gordon should be fit despite withdrawing from the Scotland squad with a knee problem.
The Black Cats will assess midfielder Jordan Henderson, who missed England Under-21 duty because of injury.
Tottenham are without injured duo Gareth Bale and Rafael van der Vaart, although both could play in Tuesday's Champions League tie at AC Milan.
Peter Crouch is doubtful with the back problem that ruled him out of England's friendly against Denmark.
With Chelsea not in action until Monday, victory on Wearside will take Tottenham into a top-four spot and provide a timely boost ahead of their Champions League trip to AC Milan.
Sunderland also have European ambitions of their own, and while Europa League qualification looks their best bet, a win on Saturday would leave the Black Cats just four points behind Spurs.
Steve Bruce's side were beaten 4-2 by Chelsea in their last game at the Stadium of Light, but they have generally enjoyed entertaining the Premier League elite this season; they have held Ars*nal and Manchester United and beat Manchester City.
It is a decade since Tottenham last won on Wearside, and if they are to end that wait they may have to find a reliable penalty taker, given that the last three meetings have produced four penalties. The Londoners have missed a hatful of spot-kicks this term, including two of four awarded in Premier League games.