West Ham are bolstered by the return of Matthew Upson, Danny Gabbidon, Herita Ilunga and Winston Reid, who all sat out the League Cup win at Sunderland. Valon Behrami's knee will be assessed, but Thomas Hitzlsperger is still out.
Tottenham midfielder Luka Modric has overcome a foot injury, while Rafael van der Vaart and Vedran Corluka are also fit to play.
Benoit Assou-Ekotto and Ledley King are doubts with knee problems, and keeper Heurelho Gomes is still sidelined.
These far-from-friendly London rivals clash at Upton Park after a week in which they experienced vastly different emotions in the League Cup.
The beleaguered Hammers finally showed signs that this season is not necessarily going to be an arduous struggle with a performance against Sunderland that belied their woeful league form. Remarkably, it was the first time they had knocked out a top-flight team in the League Cup since 1997.
You also have to go back quite a way to find the last time they beat Tottenham. That match on the final day of the 2005/06 season still leaves a sour taste in the mouth of Spurs fans, as West Ham's 2-1 win over a Tottenham side suffering badly with gastroenteritis denied them a place in the Champions League.
Tottenham, of course, are now enjoying the fruits of Europe's premier cup competition, but manager Harry Redknapp has had to make some big calls on where his team are going to prioritise this season.
This meant a shadow side were dumped out of the Carling Cup by their bitterest foes Ars*nal on Tuesday. There is no chance Redknapp will not take this weekend's game seriously, and after being out-gunned by the Gunners, he is sure to unleash his full firepower on the Hammers.